Effects of iron depletion on CALM-AF10 leukemias
نویسندگان
چکیده
منابع مشابه
environmental effects of gol-e-gohar iron ore mine on groundwater of the area
gol-e-gohar iron ore mine of sirjan in southern part of iran is a large open pit that operates below the groundwater table and during mining operation, dewatering is required to prevent operation processes from flooding. current operation is going on by digging wells in or out of the pit and pumping to prevent flooding. as a result of the former dewatering operation a vast deep cone of depressi...
Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias.
Chromosomal translocations generating fusion proteins are frequently found in human leukemias. The fusion proteins play an important role in leukemogenesis by subverting the function of one or both partner proteins. The leukemogenic CALM-AF10 fusion protein is capable of interacting with the histone H3 lysine 79 (H3K79)-specific methyltransferase hDOT1L through the fused AF10 moiety. This inter...
متن کاملMYELOID NEOPLASIA Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10–positive leukemias
1State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China; 2Department of Medicine III, University of Munich Hospital Grosshaden, and German Research Center for Environmental Health, Clinical Cooperative Group “Leukemia,” Munich, Germany; 3Mass Spectrometry Facility, Department of Biochemistry, School of Medicine, Loma L...
متن کاملA CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.
The t(10;11) chromosomal translocation gives rise to the CALM-AF10 fusion gene and is found in patients with aggressive and difficult-to-treat hematopoietic malignancies. CALM-AF10-driven leukemias are characterized by HOXA gene up-regulation and a global reduction in H3K79 methylation. DOT1L, the H3K79 methyltransferase, interacts with the octapeptide/leucine zipper domain of AF10, and this re...
متن کاملNuclear export signal within CALM is necessary for CALM-AF10-induced leukemia
The CALM-AF10 fusion gene, which results from a t(10;11) translocation, is found in a variety of hematopoietic malignancies. Certain HOXA cluster genes and MEIS1 genes are upregulated in patients and mouse models that express CALM-AF10. Wild-type clathrin assembly lymphoid myeloid leukemia protein (CALM) primarily localizes in a diffuse pattern within the cytoplasm, whereas AF10 localizes in th...
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ژورنال
عنوان ژورنال: Experimental Hematology
سال: 2014
ISSN: 0301-472X
DOI: 10.1016/j.exphem.2014.08.004